Open AccessIntravitreous Injection of Interleukin-6 Leads to a Sprouting in the Retinotectal Pathway at Different Stages of Development
Author(s) -
Grasielle Duarte Menezes,
Vanessa Gama Goulart,
Sheila Espírito-Santo,
Priscilla Oliveira-Silva,
Claudio Alberto Serfaty,
Paula Campello-Costa
Publication year - 2016
Publication title -
neuroimmunomodulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.635
H-Index - 65
eISSN - 1423-0216
pISSN - 1021-7401
DOI - 10.1159/000444529
Subject(s) - superior colliculus , sprouting , neuroscience , axon , axon guidance , retinal , biology , central nervous system , biochemistry , botany
The development of retinotectal pathways form precise topographical maps is usually completed by the third postnatal week. Cytokines participate in the development and plasticity of the nervous system. We have previously shown that in vivo treatment with interleukin 2 disrupts the retinocollicular topographical order in early stages of development. Therefore, we decided to study the effect of a single intravitreous injection of IL-6 upon retinotectal circuitry in neonates and juvenile rats.