Open AccessFamiliar Papillary Thyroid Carcinoma in a Large Brazilian Family Is Not Associated with Succinate Dehydrogenase Defects
Author(s) -
Elen Dias Accordi,
Paraskevi Xekouki,
Bruna Azevedo,
Rodrigo Bertollo de Alexandre,
Carla Beatriz Frasson,
Siliane Marie Gantzel,
Georgios Z. Papadakis,
Anna Angelousi,
Constantine A. Stratakis,
Vanessa Santos Sotomaior,
Fabio R. Faucz
Publication year - 2016
Publication title -
european thyroid journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.23
H-Index - 10
eISSN - 2235-0802
pISSN - 2235-0640
DOI - 10.1159/000444522
Subject(s) - sdha , sdhd , sdhb , cancer research , thyroid cancer , thyroid carcinoma , papillary thyroid cancer , genetics , medicine , gist , paraganglioma , biology , succinate dehydrogenase , germline mutation , mutation , gene , cancer , thyroid , pathology , stromal cell , mitochondrion
Thyroid cancer is the most common endocrine gland malignancy. Advances in understanding the genetic basis for thyroid cancer revealed the potential involvement of several genes in the formation of thyroid tumors. Mutations in the gene coding for succinate dehydrogenase subtype B (SDHB) have been implicated in papillary thyroid cancer (PTC). Succinate dehydrogenase (SDH) is a heterotetrameric protein composed of four subunits, SDHA, SDHB, SDHC, and SDHD, and participates in both the electron transport chain and the tricarboxylic acid cycle. The aim of the study was to evaluate the association between variants in the SDHA, SDHB, SDHC, and SDHD genes and familiar PTC in a large Brazilian family.