Neuroserpin Protects Rat Neurons and Microglia-Mediated Inflammatory Response Against Oxygen-Glucose Deprivation- and Reoxygenation Treatments in an In Vitro Study | Zendy

Xuelian Yang | Zendy; Tetsuya Asakawa | Zendy; Han Sha | Zendy; Ling Liu | Zendy; Wei Li | Zendy; WeiWen Wu | Zendy; Yunhe Luo | Zendy; Wenjie Cao | Zendy; Xin Cheng | Zendy; BaoGuo Xiao | Zendy; Hiroki Namba | Zendy; Chuanzhen Lü | Zendy; Qiang Dong | Zendy; Liang Wang | Zendy

Open Access

Neuroserpin Protects Rat Neurons and Microglia-Mediated Inflammatory Response Against Oxygen-Glucose Deprivation- and Reoxygenation Treatments in an In Vitro Study

Author(s) -

Xuelian Yang,

Tetsuya Asakawa,

Han Sha,

Ling Liu,

Wei Li,

WeiWen Wu,

Yunhe Luo,

Wenjie Cao,

Xin Cheng,

BaoGuo Xiao,

Hiroki Namba,

Chuanzhen Lü,

Qiang Dong,

Liang Wang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443089

Subject(s) - microglia , in vitro , inflammatory response , inflammation , chemistry , pharmacology , neuroinflammation , neuroscience , medicine , endocrinology , biology , biochemistry

Neuroserpin (NSP) is known for its neuroprotective role in cerebral ischemic animal models and patients. Our laboratory conducted a series of investigations on the neuroprotection of NSP in different cells in the brain. In the present study, we further observe the effects of NSP on neurons and microglia-mediated inflammatory response following oxygen-glucose deprivation (OGD), and explore possible mechanisms related to neuroprotection of OGD in the central nervous system (CNS).

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