Open AccessNeuroserpin Protects Rat Neurons and Microglia-Mediated Inflammatory Response Against Oxygen-Glucose Deprivation- and Reoxygenation Treatments in an In Vitro Study
Author(s) -
Xuelian Yang,
Tetsuya Asakawa,
Han Sha,
Ling Liu,
Wei Li,
WeiWen Wu,
Yansheng Luo,
Wenjie Cao,
Xin Cheng,
BaoGuo Xiao,
Hiroki Namba,
Chuanzhen Lü,
Qiang Dong,
Liang Wang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000443089
Subject(s) - microglia , in vitro , inflammatory response , inflammation , chemistry , pharmacology , neuroinflammation , neuroscience , medicine , endocrinology , biology , biochemistry
Neuroserpin (NSP) is known for its neuroprotective role in cerebral ischemic animal models and patients. Our laboratory conducted a series of investigations on the neuroprotection of NSP in different cells in the brain. In the present study, we further observe the effects of NSP on neurons and microglia-mediated inflammatory response following oxygen-glucose deprivation (OGD), and explore possible mechanisms related to neuroprotection of OGD in the central nervous system (CNS).