Open AccessProtective Effects of Colivelin Against Alzheimer's Disease in a PDAPP Mouse Model
Author(s) -
Rong Yin,
Kang Yin,
Zhiqiang Guo,
Zhiqiang Zhang,
Lipin Chen,
Li Cao,
YuanMin Li,
Yaxuan Wei,
Xuefeng Fu,
Xiangqun Shi
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000443064
Subject(s) - apoptosis , neuroprotection , morris water navigation task , genetically modified mouse , western blot , inflammation , tunel assay , immunohistochemistry , transgene , pharmacology , immunology , medicine , chemistry , cancer research , microbiology and biotechnology , biology , endocrinology , hippocampus , biochemistry , gene
Alzheimer's disease (AD) is characterized with progressive memory loss and severe cognitive impairments, which affect everyday life and human health in the elderly. It is required that an effective and safe protective reagent against AD should be developed. It has been reported that humanin (HN) exerts neuroprotective effects against AD. In this study, we investigated the effect of a novel and more effective HN derivative, Colivelin (CLN) on AD.