Macrophage CGI-58 Attenuates Inflammatory Responsiveness via Promotion of PPARγ Signaling | Zendy

Dan Yang | Zendy; Haimei Chen | Zendy; Xu Zeng | Zendy; Ping Xie | Zendy; XinCun Wang | Zendy; Chang Liu | Zendy

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Macrophage CGI-58 Attenuates Inflammatory Responsiveness via Promotion of PPARγ Signaling

Author(s) -

Dan Yang,

Haimei Chen,

Xu Zeng,

Ping Xie,

XinCun Wang,

Chang Liu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443027

Subject(s) - adipose triglyceride lipase , inflammation , endocrinology , proinflammatory cytokine , peroxisome proliferator activated receptor , medicine , gene knockdown , lipolysis , chemistry , mitochondrial biogenesis , lipopolysaccharide , receptor , microbiology and biotechnology , biology , adipose tissue , mitochondrion , apoptosis , biochemistry

Comparative gene identification-58 (CGI-58), an adipose triglyceride lipase (ATGL) coactivator, strongly promotes ATGL-mediated triglyceride (TG) catabolism. Beyond its function in promoting lipolysis, other features of CGI-58 have been proposed. Here, we investigated the role of CGI-58 in the regulation of inflammatory responsiveness in macrophages.

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