Dendritic Cell-T-Cell Circuitry in Health and Changes in Inflammatory Bowel Disease and Its Treatment | Zendy

Stella C. Knight | Zendy

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Dendritic Cell-T-Cell Circuitry in Health and Changes in Inflammatory Bowel Disease and Its Treatment

Author(s) -

Stella C. Knight

Publication year - 2016

Publication title -

digestive diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 66

eISSN - 1421-9875

pISSN - 0257-2753

DOI - 10.1159/000442926

Subject(s) - homing (biology) , immune system , immunology , acquired immune system , medicine , t cell , antigen , dendritic cell , lymphocyte homing receptor , antigen presenting cell , biology , cell , ecology , cell adhesion , genetics

Dendritic, antigen-presenting cells (DCs) determine not only whether lymphocytes produce different types of immune response but also tissue-homing profiles of lymphocytes they stimulate. For example, in health, mucosal DC stimulate T cells focused to home to the mucosa; DC/T-cell circuitry thus targets immune responses to specific tissue locations. Therapies being introduced for inflammatory bowel disease (IBD) include antibodies to gut-homing molecules such as α4β7 (Vedolizumab) used ostensibly to block gut-homing lymphocytes. However, such lymphocytes are dependent on the tissue specificity of DC that stimulated them.

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