Open AccessDocosahexaenoic Acid-Rich Fish Oil Supplementation Improves Body Composition without Influence of the PPARγ Pro12Ala Polymorphism in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Author(s) -
Anahita Mansoori,
Gity Sotoudeh,
Mahmoud Djalali,
M R Eshraghian,
Mohammad Keramatipour,
Ensieh Naslı-Esfahani,
Farzad Shidfar,
Ehsan Alvandi,
Omid Toupchian,
Fariba Koohdani
Publication year - 2015
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000442792
Subject(s) - medicine , adiponectin , endocrinology , fish oil , docosahexaenoic acid , type 2 diabetes , peroxisome proliferator activated receptor , biology , obesity , diabetes mellitus , insulin resistance , polyunsaturated fatty acid , fatty acid , receptor , biochemistry , fishery , fish <actinopterygii>
The aims of this research were to investigate (1) the impact of docosahexaenoic acid (DHA)-rich fish oil supplementation on body composition, plasma adiponectin level, and peroxisome proliferator-activated receptor γ (PPARγ) gene expression, and (2) whether the effect of DHA-rich fish oil supplementation on the aforementioned variables is modulated by PPARγ Pro12Ala polymorphism.