Nogo-p4 Suppresses TrkA Signaling Induced by Low Concentrations of Nerve Growth Factor Through NgR1 in Differentiated PC12 Cells | Zendy

YouMing Fan | Zendy; Qingyuan Huang | Zendy; Yin-Ai Wu | Zendy; Alan R. Harvey | Zendy; Qi Cui | Zendy; Yu-Qi Gao | Zendy

Open Access

Nogo-p4 Suppresses TrkA Signaling Induced by Low Concentrations of Nerve Growth Factor Through NgR1 in Differentiated PC12 Cells

Author(s) -

YouMing Fan,

Qingyuan Huang,

Yin-Ai Wu,

Alan R. Harvey,

Qi Cui,

Yu-Qi Gao

Publication year - 2016

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000442609

Subject(s) - nerve growth factor , tropomyosin receptor kinase a , neurite , microbiology and biotechnology , low affinity nerve growth factor receptor , chemistry , signal transduction , protein kinase b , axon , neurotrophin , neuroscience , biology , receptor , biochemistry , in vitro

Regeneration of injured axons in adult mammalian central nervous system (CNS) is not spontaneous. Nogo is a major inhibitory molecule contributing to axon regeneration failure. The molecular mechanisms of Nogo inhibition of axon regeneration are not completely understood. To further investigate the underlying mechanisms, we studied the effects of Nogo-p4, a 25-amino acid core inhibitory fragment of Nogo, on nerve growth factor (NGF)-induced TrkA signaling.

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