Open AccessInhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression
Author(s) -
Heike Grassmé,
Peter L. Jernigan,
Richard S. Hoehn,
Barbara Wilker,
Matthias Soddemann,
Michael J. Edwards,
Christian P. Müller,
Johannes Kornhuber,
Erich Gulbins
Publication year - 2015
Publication title -
neurosignals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.755
H-Index - 67
eISSN - 1424-8638
pISSN - 1424-862X
DOI - 10.1159/000442606
Subject(s) - acid sphingomyelinase , neurogenesis , corticosterone , ceramide , hippocampus , hippocampal formation , antidepressant , endocrinology , behavioural despair test , pharmacology , phosphorylation , medicine , kinase , chemistry , microbiology and biotechnology , biology , biochemistry , apoptosis , hormone
Major depressive disorder is a common disease with serious morbidity, including increased risk of death from suicide. Major depressive disorder is treated with antidepressants. However, the molecular targets of antidepressants remained ill-defined and require further elucidation.