Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression | Zendy

Heike Grassmé | Zendy; Peter L. Jernigan | Zendy; Richard S. Hoehn | Zendy; Barbara Wilker | Zendy; Matthias Soddemann | Zendy; Michael J. Edwards | Zendy; Christian P. Müller | Zendy; Johannes Kornhuber | Zendy; Erich Gulbins | Zendy

Open Access

Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression

Author(s) -

Heike Grassmé,

Peter L. Jernigan,

Richard S. Hoehn,

Barbara Wilker,

Matthias Soddemann,

Michael J. Edwards,

Christian P. Müller,

Johannes Kornhuber,

Erich Gulbins

Publication year - 2015

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000442606

Subject(s) - acid sphingomyelinase , neurogenesis , corticosterone , ceramide , hippocampus , hippocampal formation , antidepressant , endocrinology , behavioural despair test , pharmacology , phosphorylation , medicine , kinase , chemistry , microbiology and biotechnology , biology , biochemistry , apoptosis , hormone

Major depressive disorder is a common disease with serious morbidity, including increased risk of death from suicide. Major depressive disorder is treated with antidepressants. However, the molecular targets of antidepressants remained ill-defined and require further elucidation.

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