JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report | Zendy

Serena Delbue | Zendy; Carlo Sebastiano Tadeo | Zendy; Francesca Elia | Zendy; Pasquale Ferrante | Zendy

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JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report

Author(s) -

Serena Delbue,

Carlo Sebastiano Tadeo,

Francesca Elia,

Pasquale Ferrante

Publication year - 2015

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000441473

Subject(s) - natalizumab , progressive multifocal leukoencephalopathy , multiple sclerosis , jc virus , cerebrospinal fluid , etiology , medicine , virology , demyelinating disease , virus , leukoencephalopathy , immunology , pathology , disease

Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies.

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