Open AccessJC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report
Author(s) -
Serena Delbue,
Carlo Sebastiano Tadeo,
Francesca Elia,
Pasquale Ferrante
Publication year - 2015
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000441473
Subject(s) - natalizumab , progressive multifocal leukoencephalopathy , multiple sclerosis , jc virus , cerebrospinal fluid , etiology , medicine , virology , demyelinating disease , virus , leukoencephalopathy , immunology , pathology , disease
Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies.