Open AccessChikungunya Virus Infection Alters Expression of MicroRNAs Involved in Cellular Proliferation, Immune Response and Apoptosis
Author(s) -
Anuj Sharma,
Nagaraja S. Balakathiresan,
Radha K. Maheshwari
Publication year - 2015
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000441309
Subject(s) - chikungunya , biology , microrna , virus , virology , western blot , immune system , signal transduction , immunology , microbiology and biotechnology , gene , genetics
Chikungunya virus (CHIKV) is a reemerging virus of significant importance that has caused large-scale outbreaks in the countries with a temperate climate. CHIKV causes debilitating arthralgia which can persist for weeks and up to a year. Fibroblast cells are the main target of CHIKV infection. In this study, we analyzed microRNA (miRNA) modulation in the fibroblast cells infected with CHIKV at an early stage of infection.