Effect of Nonstructural Protein 2 Hypervariable Regions in the Replication of Porcine Reproductive and Respiratory Syndrome Virus in Marc-145 Cells | Zendy

Ying Liu | Zendy; Feng-Xue Wang | Zendy; Yongjun Wen | Zendy; Zhenguang Li | Zendy; Xing Liu | Zendy; Na Sun | Zendy; Yong Yang | Zendy; Shuqin Zhang | Zendy; Hongwei Zhu | Zendy; Shipeng Cheng | Zendy; Hua Wu | Zendy

Open Access

Effect of Nonstructural Protein 2 Hypervariable Regions in the Replication of Porcine Reproductive and Respiratory Syndrome Virus in Marc-145 Cells

Author(s) -

Ying Liu,

Feng-Xue Wang,

Yongjun Wen,

Zhenguang Li,

Xing Liu,

Na Sun,

Yong Yang,

Shuqin Zhang,

Hongwei Zhu,

Shipeng Cheng,

Hua Wu

Publication year - 2015

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000440977

Subject(s) - porcine reproductive and respiratory syndrome virus , biology , virus , microbiology and biotechnology , viral replication , virology , titer , transfection , plasmid , cell culture , gene , genetics

Highly pathogenic (HP) porcine reproductive and respiratory syndrome virus (PRRSV) causes prolonged high fever, red discoloration of the body, blue ears and a high mortality. Previously, we found that the PRRSV vaccine strain TJM contained a deletion of 120 amino acids (aa 628-747) in nonstructural protein 2 (Nsp2). We aimed to explore the replication features of PRRSV after adding the transiently expressed product of these 120 aa in vitro.

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