Open AccessSilencing of ATPase Inhibitory Factor 1 Inhibits Cell Growth via Cell Cycle Arrest in Bladder Cancer
Author(s) -
Shihu Wei,
Hideo Fukuhara,
Chiaki Kawada,
Atsushi Kurabayashi,
Mutsuo Furihata,
Shunichiro Ogura,
Keiji Inoue,
Taro Shuin
Publication year - 2015
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000439027
Subject(s) - cell cycle , cell growth , microbiology and biotechnology , cyclin d1 , biology , cyclin dependent kinase 6 , cyclin b1 , chemistry , cell , cyclin dependent kinase 1 , biochemistry
The role of the ATPase inhibitory factor 1 (IF1) is inhibit the hydrolase activity of F1Fo-ATPase when oxidative phosphorylation is impaired. It has been demonstrated that IF1 is overexpressed in various carcinomas and mediates tumor cell activities, but the detailed mechanisms of IF1-mediated tumor progression and the link between IF1 and cell cycle progression remain unclear. Herein, we aimed to investigate the potential role of IF1 in cell cycle progression of human bladder cancer (BCa).