Open AccessApoptosis of THP-1 Macrophages Induced by Pseudohypericin-Mediated Sonodynamic Therapy Through the Mitochondria-Caspase Pathway
Author(s) -
Xiufeng Zheng,
Jinrong Wu,
Qun Shao,
Xuesong Li,
Jiayuan Kou,
Xing Zhu,
Zhaoyu Zhong,
Yueqing Jiang,
Zhongni Liu,
Hongxia Li,
Ye Tian,
Liming Yang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438649
Subject(s) - sonodynamic therapy , apoptosis , cytochrome c , hypericin , viability assay , mitochondrial permeability transition pore , thp1 cell line , reactive oxygen species , chemistry , mitochondrion , mptp , microbiology and biotechnology , apoptosome , caspase , biology , pharmacology , programmed cell death , biochemistry , cell culture , genetics , dopaminergic , neuroscience , dopamine
Pseudohypericin (P-HY) and its congener hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Our previous study indicated that hypericin was able to function as a sonosensitizer. The potential use of P-HY as a sonosensitizer for sonodynamic therapy (SDT) requires further exploration. Thus, this study aimed to investigate the effects of P-HY-SDT on THP-1 macrophages.