Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis | Zendy

Jun Wang | Zendy; Ya Zhuo | Zendy; Lei Yin | Zendy; Hui Wang | Zendy; Yanqiu Jiang | Zendy; Xia Liu | Zendy; Miaomiao Zhang | Zendy; F. Du | Zendy; Sheng Xia | Zendy; Qixiang Shao | Zendy

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Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis

Author(s) -

Jun Wang,

Ya Zhuo,

Lei Yin,

Hui Wang,

Yanqiu Jiang,

Xia Liu,

Miaomiao Zhang,

F. Du,

Sheng Xia,

Qixiang Shao

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438642

Subject(s) - apoptosis , mapk/erk pathway , mitomycin c , biology , microbiology and biotechnology , cancer research , signal transduction , chemistry , immunology , biochemistry , genetics

Age-associated and stress-induced involution of the thymus is accompanied by reduced numbers of thymic epithelial cells (TECs) and severe reduction in peripheral T cell repertoire specificities. These events seriously affect immune function, but the mechanisms involved are unclear. Our preliminary findings showed that doxycycline (Dox) could drive the proliferation of a TEC line (MTEC1 cells) partially via the MAPK signaling pathway. Dox can also up-regulate IL-6 and GM-CSF expression via the NF-κB and MAPK/ERK pathways. Herein, we investigate the effects and mechanisms used by Dox that protect against mitomycin C (MMC)-induced MTEC1 cell apoptosis.

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