Open AccessSGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5)
Author(s) -
Musaab Ahmed,
Myriam Fezai,
Néstor L. Uzcátegui,
Zohreh Hosseinzadeh,
Florian Läng
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438636
Subject(s) - nedd4 , xenopus , regulator , hek 293 cells , microbiology and biotechnology , ubiquitin ligase , chemistry , biology , biochemistry , ubiquitin , gene
The serum & glucocorticoid inducible kinase isoform SGK3 is a powerful regulator of several transporters, ion channels and the Na+/K+ ATPase. Targets of SGK3 include the ubiquitin ligase Nedd4-2, which is in turn a known regulator of the voltage gated K+ channel Kv1.5 (KCNA5). The present study thus explored whether SGK3 modifies the activity of the voltage gated K+ channel KCNA5, which participates in the regulation of diverse functions including atrial cardiac action potential, activity of vascular smooth muscle cells, insulin release and tumour cell proliferation.