z-logo
open-access-imgOpen Access
SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5)
Author(s) -
Musaab Ahmed,
Myriam Fezai,
Néstor L. Uzcátegui,
Zohreh Hosseinzadeh,
Florian Läng
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438636
Subject(s) - nedd4 , xenopus , regulator , hek 293 cells , microbiology and biotechnology , ubiquitin ligase , chemistry , biology , biochemistry , ubiquitin , gene
The serum & glucocorticoid inducible kinase isoform SGK3 is a powerful regulator of several transporters, ion channels and the Na+/K+ ATPase. Targets of SGK3 include the ubiquitin ligase Nedd4-2, which is in turn a known regulator of the voltage gated K+ channel Kv1.5 (KCNA5). The present study thus explored whether SGK3 modifies the activity of the voltage gated K+ channel KCNA5, which participates in the regulation of diverse functions including atrial cardiac action potential, activity of vascular smooth muscle cells, insulin release and tumour cell proliferation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here