Open AccessPlacental Growth Factor Promotes Ovarian Cancer Cell Invasion via ZEB2
Author(s) -
Ning Song,
Hao Líu,
Xiaoxin Ma,
Shulan Zhang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438635
Subject(s) - biology , western blot , cell growth , placental growth factor , mapk/erk pathway , cancer research , ovary , pi3k/akt/mtor pathway , protein kinase b , cell , ovarian cancer , kinase , cancer , signal transduction , microbiology and biotechnology , endocrinology , gene , genetics , vascular endothelial growth factor , vegf receptors
The aggressive manner of ovarian cancer (OVC) cells accounts for the majority of its lethality. Recently, we have shown that placental growth factor (PLGF) promotes metastases of OVC cells through miR-543-regulated MMP7. In the current study, we analyzed the effects of PLGF on another cell invasion associated protein, ZEB2, in OVC cells.