Oxaliplatin Induced Suicidal Death of Human Erythrocytes | Zendy

Antonella Fazio | Zendy; Marilena Briglia | Zendy; Caterina Faggio | Zendy; Kousi Alzoubi | Zendy; Florian Läng | Zendy

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Oxaliplatin Induced Suicidal Death of Human Erythrocytes

Author(s) -

Antonella Fazio,

Marilena Briglia,

Caterina Faggio,

Kousi Alzoubi,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438592

Subject(s) - phosphatidylserine , apoptosis , reactive oxygen species , oxidative stress , chemistry , oxaliplatin , annexin , pharmacology , cytosol , biochemistry , biophysics , microbiology and biotechnology , phospholipid , biology , medicine , membrane , cancer , colorectal cancer , enzyme

The alkylating drug oxaliplatin is widely used for chemotherapy of malignancy. Oxaliplatin is effective by inducing both, necrosis and apoptosis. Similar to necrosis or apoptosis of nucleated cells, erythrocytes may enter hemolysis, which is apparent from hemoglobin release or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include oxidative stress and/or Ca2+ entry with increase of cytosolic Ca2+ activity ([Ca2+]i). The present study explored, whether and how oxaliplatin induces eryptosis.

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