Open AccessLeukotriene B4 Inhibits L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells
Author(s) -
Xiaoyu Liu,
Tingting Yang,
Langxi Miao,
YanAi Mei,
Changlong Hu
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438551
Subject(s) - vascular smooth muscle , leukotriene b4 , t type calcium channel , calcium channel , l type calcium channel , voltage dependent calcium channel , calcium , protein kinase c , signal transduction , biology , endocrinology , microbiology and biotechnology , medicine , chemistry , inflammation , smooth muscle
Arachidonic acid (AA) and its metabolites are important endogenous lipid messengers. In this study, we test the effect of Leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of AA, on L-type calcium channels in A7r5 rat aortic vascular smooth muscle cells.