Open AccessDickkopf1 Up-Regulation Induced by a High Concentration of Dexamethasone Promotes Rat Tendon Stem Cells to Differentiate Into Adipocytes
Author(s) -
Wan Chen,
Hong Tang,
Xiangzhou Liu,
Mei Zhou,
Jiqiang Zhang,
Kanglai Tang
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438538
Subject(s) - wnt signaling pathway , blot , dkk1 , adipogenesis , catenin , chemistry , downregulation and upregulation , gsk3b , gene knockdown , cellular differentiation , microbiology and biotechnology , gsk 3 , transdifferentiation , signal transduction , stem cell , medicine , endocrinology , biology , adipose tissue , biochemistry , apoptosis , gene
Dexamethasone (Dex)-induced spontaneous tendon rupture and decreased self-repair capability is very common in clinical practice. The metaplasia of adipose tissue in the ruptured tendon indicates that Dex may induce tendon stem cells (TSCs) to differentiate into adipocytes, but the mechanism remains unclear. In the present study, we used in vitro methods to investigate the effects of Dex on rat TSC differentiation and the molecular mechanisms underlying this process.