Open AccessCo-Transplantation of Skin-Derived Precursors and Collagen Sponge Facilitates Diabetic Wound Healing by Promoting Local Vascular Regeneration
Author(s) -
Tingyu Ke,
Mei Yang,
Duo Mao,
Meifeng Zhu,
Yongzhe Che,
Deling Kong,
Chen Li
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438537
Subject(s) - wound healing , regeneration (biology) , angiogenesis , stem cell , transplantation , paracrine signalling , immunostaining , pathology , microbiology and biotechnology , medicine , biology , cancer research , immunology , surgery , immunohistochemistry , receptor
Impaired diabetes wound healing can often lead to serious complications and remains a major health concern due to the lack of effective therapeutic approaches. Compromised angiogenesis, disrupted growth factor and cytokine activity are all attributable to diabetic wound healing impairment. The skin-derived precursors (SKPs) have been shown to differentiate into vascular and nerve cells, both of which are crucial components for wound repair. Given their easy accessibility and multipotency, the SKPs were proposed as an ideal therapeutic candidate for diabetic wound healing. Since the efficacy of cell therapy is limited by poor cell survival, collagen sponge was employed for better SKPs delivery.