Open AccessTreatment of Acute Hepatitis C Infection with Pegylated Interferon and Ribavirin in Patients Coinfected with Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis
Author(s) -
Bing Zhang,
Nghia Nguyen,
Brittany E. Yee,
Benjamin Hon Kei Yip,
Walid Ayoub,
Glen Lutchman,
Mindie H. Nguyen
Publication year - 2015
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000437427
Subject(s) - ribavirin , medicine , gastroenterology , pegylated interferon , hepatitis c virus , hepatitis c , meta analysis , hepatitis b , virology , immunology , virus
Of the 35 million human immunodeficiency virus (HIV)-positive patients worldwide, 10-40% are coinfected with chronic hepatitis C virus (HCV). Compared to HCV-monoinfected patients, those coinfected experience decreased spontaneous HCV clearance, accelerated liver fibrosis, and a decreased response to anti-HCV therapy. We conducted a meta-analysis to estimate the efficacy of treating acute HCV in HIV-positive patients with peginterferon and ribavirin combination therapy.