Open AccessComputational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction
Author(s) -
Le Min,
Min Nie,
Anna Zhang,
Junping Wen,
Sekoni D. Noel,
Vivian Lee,
Rona S. Carroll,
Ursula B. Kaiser
Publication year - 2015
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000435884
Subject(s) - missense mutation , ensembl , biology , genetics , g protein coupled receptor , phenotype , concordance , loss function , computational biology , genome , gene , receptor , genomics
Many missense variants in G protein-coupled receptors (GPCRs) involved in the neuroendocrine regulation of reproduction have been identified by phenotype-driven or large-scale exome sequencing. Computational functional prediction analysis is commonly performed to evaluate their impact on receptor function.