Fenofibrate Reverses Palmitate Induced Impairment in Glucose Uptake in Skeletal Muscle Cells by Preventing Cytosolic Ceramide Accumulation | Zendy

Sudarshan Bhattacharjee | Zendy; Nabanita Das | Zendy; Ashok Mandala | Zendy; Satinath Mukhopadhyay | Zendy; Sib Sankar Roy | Zendy

Open Access

Fenofibrate Reverses Palmitate Induced Impairment in Glucose Uptake in Skeletal Muscle Cells by Preventing Cytosolic Ceramide Accumulation

Author(s) -

Sudarshan Bhattacharjee,

Nabanita Das,

Ashok Mandala,

Satinath Mukhopadhyay,

Sib Sankar Roy

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430399

Subject(s) - endocrinology , medicine , insulin resistance , ceramide , glucose uptake , fenofibrate , biology , insulin , chemistry , biochemistry , apoptosis

The lipid induced insulin resistance is a major pathophysiologic mechanism underlying glucose intolerance of varying severity. PPARα-agonists are proven as effective hypolipidemic agents. The aim of this study was to see if impaired glucose uptake in palmitate treated myotubes is reversed by fenofibrate.

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