Open AccessFenofibrate Reverses Palmitate Induced Impairment in Glucose Uptake in Skeletal Muscle Cells by Preventing Cytosolic Ceramide Accumulation
Author(s) -
Sudarshan Bhattacharjee,
Nandini Das,
Ashok Mandala,
Satinath Mukhopadhyay,
Sib Sankar Roy
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430399
Subject(s) - endocrinology , medicine , insulin resistance , ceramide , glucose uptake , fenofibrate , biology , insulin , chemistry , biochemistry , apoptosis
The lipid induced insulin resistance is a major pathophysiologic mechanism underlying glucose intolerance of varying severity. PPARα-agonists are proven as effective hypolipidemic agents. The aim of this study was to see if impaired glucose uptake in palmitate treated myotubes is reversed by fenofibrate.