Histone Demethylase JMJD2A Inhibition Attenuates Neointimal Hyperplasia in the Carotid Arteries of Balloon-Injured Diabetic Rats via Transcriptional Silencing: Inflammatory Gene Expression in Vascular Smooth Muscle Cells | Zendy

Hu Qi | Zendy; Jing Zhang | Zendy; Xiaolin Wu | Zendy; Xu Changwu | Zendy; Xiaorong Hu | Zendy; Jian Yang | Zendy; Jing Chen | Zendy; Hong Jiang | Zendy

Open Access

Histone Demethylase JMJD2A Inhibition Attenuates Neointimal Hyperplasia in the Carotid Arteries of Balloon-Injured Diabetic Rats via Transcriptional Silencing: Inflammatory Gene Expression in Vascular Smooth Muscle Cells

Author(s) -

Hu Qi,

Jing Zhang,

Xiaolin Wu,

Xu Changwu,

Xiaorong Hu,

Jian Yang,

Jing Chen,

Hong Jiang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430390

Subject(s) - neointimal hyperplasia , restenosis , vascular smooth muscle , neointima , medicine , inflammation , small interfering rna , endocrinology , cancer research , chemistry , stent , transfection , biochemistry , smooth muscle , gene

Diabetic patients suffer from severe neointimal hyperplasia following angioplasty. The epigenetic abnormalities are increasingly considered to be relevant to the pathogenesis of diabetic cardiovascular complications. But the epigenetic mechanisms linking diabetes and coronary restenosis have not been fully elucidated. In this study, we explored the protective effect and underlying mechanisms of demethylases JMJD2A inhibition in balloon-injury induced neointimal formation in diabetic rats.

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