Open AccessHistone Demethylase JMJD2A Inhibition Attenuates Neointimal Hyperplasia in the Carotid Arteries of Balloon-Injured Diabetic Rats via Transcriptional Silencing: Inflammatory Gene Expression in Vascular Smooth Muscle Cells
Author(s) -
Qi Hu,
Jing Zhang,
Xiaolin Wu,
Cheng Xu,
Xiaorong Hu,
Jian Yang,
Jing Chen,
Hong Jiang
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430390
Subject(s) - neointimal hyperplasia , restenosis , vascular smooth muscle , small interfering rna , neointima , medicine , inflammation , endocrinology , cancer research , chemistry , stent , transfection , biochemistry , smooth muscle , gene
Diabetic patients suffer from severe neointimal hyperplasia following angioplasty. The epigenetic abnormalities are increasingly considered to be relevant to the pathogenesis of diabetic cardiovascular complications. But the epigenetic mechanisms linking diabetes and coronary restenosis have not been fully elucidated. In this study, we explored the protective effect and underlying mechanisms of demethylases JMJD2A inhibition in balloon-injury induced neointimal formation in diabetic rats.