Open AccessThe Impact of a Non-Functional Thyroid Receptor Beta upon Triiodotironine-Induced Cardiac Hypertrophy in Mice
Author(s) -
Güínever E. Império,
Isalira Peroba Ramos,
Leandro Santiago,
Guilherme Faria Pereira,
Norma Aparecida dos Santos Almeida,
César Seigi Fuziwara,
Carmen C. PazosMoura,
Edna Teruko Kimura,
Emerson Lopes Olivares,
Tânia Maria Ortiga-Carvalho
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430370
Subject(s) - medicine , endocrinology , cardiac function curve , thyroid , muscle hypertrophy , myh7 , receptor , hormone , biology , gene expression , ejection fraction , gene isoform , myh6 , gene , heart failure , biochemistry
Thyroid hormone (TH) signalling is critical for heart function. The heart expresses thyroid hormone receptors (THRs); THRα1 and THRβ1. We aimed to investigate the regulation mechanisms of the THRβ isoform, its association with gene expression changes and implications for cardiac function.