Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease | Zendy

Zhen Liu | Zendy; Cunfu Wang | Zendy; Xiao Wang | Zendy; Shunliang Xu | Zendy

Open Access

Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease

Author(s) -

Zhen Liu,

Cunfu Wang,

Xiao Wang,

Shunliang Xu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430356

Subject(s) - mesenchymal stem cell , genetically modified mouse , transplantation , neurotrophic factors , biology , transgene , stem cell , brain derived neurotrophic factor , cancer research , morris water navigation task , immunology , medicine , microbiology and biotechnology , endocrinology , hippocampus , receptor , gene , biochemistry

Alzheimer's disease (AD) is one of the most common dementias among aged people, and is clinically characterized by progressive memory loss, behavioral and learning dysfunction and cognitive deficits. So far, this is no cure for AD. A therapeutic effect of transplantation of mesenchymal stem cells (MSCs) into murine model of AD has been reported, but remains to be further improved. Brn-4 is a transcription factor that plays a critical role in neuronal development, whereas the effects of Brn-4 overexpression in transplanted MSCs on AD are unknown.

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