Open AccessEscin Increases the Survival Rate of LPS-Induced Septic Mice Through Inhibition of HMGB1 Release from Macrophages
Author(s) -
Yajun Cheng,
Hongrui Wang,
Min Mao,
Chao Liang,
Yu Zhang,
Deijun Yang,
Ziran Wei,
Shunxiang Gao,
Bo Hu,
Lianghua Wang,
Qing-Qing Cai
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430320
Subject(s) - hmgb1 , western blot , lipopolysaccharide , tumor necrosis factor alpha , proinflammatory cytokine , macrophage , interleukin 6 , chemistry , pharmacology , inflammation , immunology , medicine , in vitro , biochemistry , gene
Previous studies have described the effects of Escin on improving the survival rate of endotoxemic animals. The purpose of this study was to explore the molecular mechanisms of this potentially beneficial treatment.