Open AccessRegulation of Na+/H+ Exchanger in Dendritic Cells by Akt1
Author(s) -
Yuetao Zhou,
Venkanna Pasham,
Soumya Chatterjee,
Anand Rotte,
Wenting Yang,
Madhuri Bhandaru,
Yogesh Singh,
Florian Läng
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430293
Subject(s) - akt1 , protein kinase b , chemistry , sodium–hydrogen antiporter , microbiology and biotechnology , phosphorylation , stimulation , biology , biochemistry , endocrinology , sodium , organic chemistry
Dendritic cells (DCs), antigen-presenting cells critically important for primary immune response and establishment of immunological memory, are activated by bacterial lipopolysaccharides (LPS) resulting in stimulation of Na(+)/H(+) exchanger, ROS formation and migration. The effects are dependent on phosphoinositide 3 (PI3) kinase and paralleled by Akt phosphorylation. The present study explored the contribution of the Akt isoform Akt1.