Open AccessCigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle
Author(s) -
Venkatachalem Sathish,
Michele Freeman,
Emma Long,
Michael A. Thompson,
Christina M. Pabelick,
Y. S. Prakash
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430282
Subject(s) - medicine , endocrinology , estrogen , contractility , estrogen receptor , agonist , respiratory system , receptor , cancer , breast cancer
Cigarette smoke (CS) in active smokers and second-hand smoke exposure exacerbate respiratory disorders such as asthma and chronic bronchitis. While women are known to experience a more asthmatic response to CS than emphysema in men, there is limited information on the mechanisms of CS-induced airway dysfunction. We hypothesize that CS interferes with a normal (protective) bronchodilatory role of estrogens, thus worsening airway contractility.