Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics | Zendy

Hao Liu | Zendy; Ping Mao | Zendy; Jia Wang | Zendy; Tuo Wang | Zendy; Chang-Hou Xie | Zendy

Open Access

Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics

Author(s) -

Hao Liu,

Ping Mao,

Jia Wang,

Tuo Wang,

Chang-Hou Xie

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430271

Subject(s) - allicin , oxidative stress , mitochondrion , mitochondrial biogenesis , viability assay , reactive oxygen species , lipid peroxidation , mitochondrial ros , cytochrome c , microbiology and biotechnology , biology , mitochondrial respiratory chain , apoptosis , chemistry , biochemistry

Parkinson disease (PD) is a common adult-onset neurodegenerative disorder, and PD related neuronal injury is associated with oxidative stress and mitochondrial dysfunction. Allicin, the main biologically active compound derived from garlic, has been shown to exert various anti-oxidative and anti-apoptotic activities in in vitro and in vivo studies.

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