Open AccessAntidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation
Author(s) -
Guifen Qiang,
Xiuying Yang,
Lili Shi,
Hengai Zhang,
Bainian Chen,
Yan Zhao,
Mian Zu,
Dan Zhou,
Jing Guo,
Haiguang Yang,
Li Zhang,
Guanhua Du
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430258
Subject(s) - ampk , medicine , endocrinology , amp activated protein kinase , protein kinase b , glut4 , glucose uptake , skeletal muscle , protein kinase a , glucose transporter , chemistry , streptozotocin , diabetes mellitus , kinase , signal transduction , insulin , biochemistry
Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which is a traditional Chinese medicine widely used to treat cardiovascular diseases. However, little is known about its antidiabetic effect. Our study aimed to investigate the in vivo and in vitro antidiabetic effect of SalA and the underlying mechanisms.