Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress | Zendy

Wen-Wei Liang | Zendy; Chunhui Zhu | Zendy; Feng Liu | Zendy; Weiding Cui | Zendy; Qing Wang | Zendy; Zhefeng Chen | Zendy; Qijia Zhou | Zendy; Shun Xu | Zendy; Chenjun Zhai | Zendy; Weimin Fan | Zendy

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Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Author(s) -

Wen-Wei Liang,

Chunhui Zhu,

Feng Liu,

Weiding Cui,

Qing Wang,

Zhefeng Chen,

Qijia Zhou,

Shun Xu,

Chenjun Zhai,

Weimin Fan

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430253

Subject(s) - integrin , chondrocyte , microbiology and biotechnology , cartilage , tissue engineering , transfection , mechanotransduction , matrix (chemical analysis) , chemistry , collagen receptor , biology , cell , biomedical engineering , anatomy , medicine , biochemistry , gene , chromatography

Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities and functions of several non-chondrocytic cell types. Therefore, in the current study, we evaluated the effects of integrin β1 up-regulation on periodic mechanical stress-induced chondrocyte proliferation, matrix synthesis and ERK1/2 phosphorylation in chondrocyte monolayer culture, and evaluated the quality of tissue-engineered cartilage constructed in vitro under periodic mechanical stress combined with integrin β1 up-regulation.

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