Open AccessB4G2 Induces Mitochondrial Apoptosis by the ROS-Mediated Opening of Ca2+-Dependent Permeability Transition Pores
Author(s) -
Nan Yao,
Yingjie Li,
Dongmei Zhang,
Dao-Lu Liu,
Patrick MingKuen Tang,
Anita Yiu,
Yong Li,
Weimin Chen,
Ping Lan,
Zhe Yao,
ZheSheng Chen,
WenCai Ye
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430212
Subject(s) - mitochondrial permeability transition pore , apoptosis , cytochrome c , reactive oxygen species , chemistry , intracellular , mitochondrion , poly adp ribose polymerase , microbiology and biotechnology , mitochondrial apoptosis induced channel , calcium in biology , programmed cell death , biology , biochemistry , polymerase , gene
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. At present, only sorafenib is approved to treat HCC. In this study, we found that a 23-hydroxybetulinic acid derivative, B4G2, exhibited potent antiproliferative activity in HCC cell lines.