B4G2 Induces Mitochondrial Apoptosis by the ROS-Mediated Opening of Ca2+-Dependent Permeability Transition Pores | Zendy

Nan Yao | Zendy; Yingjie Li | Zendy; Dongmei Zhang | Zendy; Dao-Lu Liu | Zendy; Patrick MingKuen Tang | Zendy; Anita Yiu | Zendy; Yong Li | Zendy; WeiMin Chen | Zendy; Ping Lan | Zendy; Zhe Yao | Zendy; ZheSheng Chen | Zendy; WenCai Ye | Zendy

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B4G2 Induces Mitochondrial Apoptosis by the ROS-Mediated Opening of Ca2+-Dependent Permeability Transition Pores

Author(s) -

Nan Yao,

Yingjie Li,

Dongmei Zhang,

Dao-Lu Liu,

Patrick MingKuen Tang,

Anita Yiu,

Yong Li,

WeiMin Chen,

Ping Lan,

Zhe Yao,

ZheSheng Chen,

WenCai Ye

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430212

Subject(s) - mitochondrial permeability transition pore , apoptosis , cytochrome c , reactive oxygen species , chemistry , intracellular , mitochondrion , poly adp ribose polymerase , microbiology and biotechnology , mitochondrial apoptosis induced channel , calcium in biology , programmed cell death , biology , biochemistry , polymerase , gene

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. At present, only sorafenib is approved to treat HCC. In this study, we found that a 23-hydroxybetulinic acid derivative, B4G2, exhibited potent antiproliferative activity in HCC cell lines.

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