An Epithelial Ca2+-Sensor Protein is an Alternative to Calmodulin to Compose Functional KCNQ1 Channels | Zendy

Atsushi Inanobe | Zendy; Chizuru Tsuzuki | Zendy; Yoshihisa Kurachi | Zendy

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An Epithelial Ca2+-Sensor Protein is an Alternative to Calmodulin to Compose Functional KCNQ1 Channels

Author(s) -

Atsushi Inanobe,

Chizuru Tsuzuki,

Yoshihisa Kurachi

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430155

Subject(s) - calmodulin , xenopus , phosphatase , microbiology and biotechnology , ion channel , protein subunit , chemistry , biology , patch clamp , potassium channel , biophysics , biochemistry , phosphorylation , gene , enzyme , receptor

KCNQ channels transport K+ ions and participate in various cellular functions. The channels directly assemble with auxiliary proteins such as a ubiquitous Ca2+- sensor protein, calmodulin (CaM), to configure the physiological properties in a tissue-specific manner. Although many CaM-like Ca2+-sensor proteins have been identified in eukaryotes, how KCNQ channels selectively interact with CaM and how the homologues modulate the functionality of the channels remain unclear.

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