Pax4 Expression does not Transduce Pancreatic Alpha Cells to Beta Cells | Zendy

Ling Chen | Zendy; Jing Zhang | Zendy; Zhuo Zhang | Zendy; Yaping Chu | Zendy; Bing Song | Zendy; Wang Cai | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Pax4 Expression does not Transduce Pancreatic Alpha Cells to Beta Cells

Author(s) -

Ling Chen,

Jing Zhang,

Zhuo Zhang,

Yaping Chu,

Bing Song,

Wang Cai

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430146

Subject(s) - pax4 , beta cell , alpha cell , reprogramming , beta (programming language) , cell culture , biology , microbiology and biotechnology , cell , endocrinology , gene expression , insulin , islet , gene , biochemistry , genetics , computer science , homeobox , programming language

The lack of available beta cells greatly limits the use of beta cell transplantation as a therapy for diabetes. Thus, generation of beta cells from other sources is substantially required. Pax4 has been shown to induce reprograming of alpha cells into beta cells during embryogenesis. Nevertheless, whether expression of Pax4 in adult alpha cells could trigger this alpha-to-beta cell reprogramming is unknown.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research