Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis | Zendy

Zongxing Yang | Zendy; Jin Yang | Zendy; Juan Wang | Zendy; Xiangyun Lu | Zendy; Changzhong Jin | Zendy; Tiansheng Xie | Zendy; Nanping Wu | Zendy

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Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis

Author(s) -

Zongxing Yang,

Jin Yang,

Juan Wang,

Xiangyun Lu,

Changzhong Jin,

Tiansheng Xie,

Nanping Wu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430121

Subject(s) - microrna , biology , latency (audio) , virus latency , gene regulatory network , messenger rna , gene expression , gene expression profiling , microarray analysis techniques , microarray , gene silencing , viral replication , gene , computational biology , genetics , microbiology and biotechnology , virus , computer science , telecommunications

The main obstacle to cure HIV infection is the existence of long-lasting latent reservoirs. Many efforts have been made to understand basal mechanisms of HIV-1 latency, in which miRNAs play an important role. However, integrated analysis of miRNA and mRNA expression in HIV-1 latency is lacking.

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