Molecular Profiling and Research of Therapeutic Targets | Zendy

Sumera Rizvi | Zendy; Gregory J. Gores | Zendy

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Molecular Profiling and Research of Therapeutic Targets

Author(s) -

Sumera Rizvi,

Gregory J. Gores

Publication year - 2015

Publication title -

digestive diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 66

eISSN - 1421-9875

pISSN - 0257-2753

DOI - 10.1159/000375347

Subject(s) - medicine , telomerase , targeted therapy , hepatocellular carcinoma , wnt signaling pathway , telomerase reverse transcriptase , carcinogenesis , cancer research , bioinformatics , oncology , cancer , genetics , gene , biology

The heterogeneous nature of hepatocellular carcinoma (HCC) poses a challenge to effective therapy. Significant strides have been made in molecular profiling. Telomerase promoter mutations are now known to represent early events in linear carcinogenesis. However, the translation of these advances into clinical practice has been limited. Although further work is needed to extrapolate genetic information to patient care, progress has been made in using genetics and stratification for HCC therapy. Targeted therapies for patients with c-MET overexpression, VEGF-A amplification and Wnt β-catenin-driven tumors offer promise.

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