Open AccessMiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil
Author(s) -
Liang Shi,
Li Wu,
Zhanguo Chen,
Jianrong Yang,
Xiaofei Chen,
Fangyou Yu,
Fang Zheng,
Xiangyang Lin
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000374036
Subject(s) - microrna , cancer research , keap1 , hepatocellular carcinoma , transcription factor , biology , apoptosis , microbiology and biotechnology , liver cancer , gene , genetics
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. A major cause for the failure of cancer therapy is the development of chemoresistance. Although progress has been made in the study of the mechanisms underlying cancer cells resistance, little is known about the role of microRNAs (miRNAs) in cancer therapy resistance.