CYP2J2 and EETs Protect Against Lung Ischemia/Reperfusion Injury via Anti-Inflammatory Effects in Vivo and in Vitro | Zendy

Wenshu Chen | Zendy; Shijiang Yang | Zendy; Ping Wei | Zendy; Xiangning Fu | Zendy; Qinzi Xu | Zendy; Jianing Wang | Zendy

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CYP2J2 and EETs Protect Against Lung Ischemia/Reperfusion Injury via Anti-Inflammatory Effects in Vivo and in Vitro

Author(s) -

Wenshu Chen,

Shijiang Yang,

Ping Wei,

Xiangning Fu,

Qinzi Xu,

Jianing Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374011

Subject(s) - epoxygenase , pharmacology , reperfusion injury , bronchoalveolar lavage , lung , inflammation , ischemia , chemistry , proinflammatory cytokine , arachidonic acid , medicine , biochemistry , enzyme

Injurious inflammatory response is critical to the development of lung ischemia/reperfusion injury (LIRI). The cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert an anti-inflammatory effect on the cardiovascular system. We therefore cytochrome hypothesized that CYP2J2 overexpression and pretreatment with exogenous EETs may have the potential to reduce LIRI.

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