Open AccessThe Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60
Author(s) -
Ayman M. Saleh,
Ahmad Aljada,
Mustafa M. ElAbadelah,
Mutasem O. Taha,
Salim S. Sabri,
Jalal A. Zahra,
Mehar Aziz
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000374003
Subject(s) - cyclin dependent kinase 2 , cyclin dependent kinase , cell cycle , kinase , chemistry , retinoblastoma protein , cell growth , cell culture , cyclin dependent kinase 1 , cyclin , microbiology and biotechnology , cancer research , biology , cell , biochemistry , genetics
The antileukemic potential of isoindigos make them desired candidates for understanding their mechanism of action. We have recently synthesized a novel group of pyridone-annelated isoindigos and identified the derivative 5'-Cl that is cytotoxic to various cancer cell lines. In the present study, we analyzed the effect of this compound on cell cycle of the promyelocytic leukemia cell line HL-60.