The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60 | Zendy

Ayman Saleh | Zendy; Ahmad Aljada | Zendy; Mustafa M. ElAbadelah | Zendy; Mutasem O. Taha | Zendy; Salim S. Sabri | Zendy; Jalal A. Zahra | Zendy; Mohammad Azhar Aziz | Zendy

Open Access

The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60

Author(s) -

Ayman Saleh,

Ahmad Aljada,

Mustafa M. ElAbadelah,

Mutasem O. Taha,

Salim S. Sabri,

Jalal A. Zahra,

Mohammad Azhar Aziz

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374003

Subject(s) - cyclin dependent kinase 2 , cyclin dependent kinase , cell cycle , kinase , chemistry , retinoblastoma protein , cell growth , cell culture , cyclin dependent kinase 1 , cyclin , microbiology and biotechnology , cancer research , biology , cell , biochemistry , genetics

The antileukemic potential of isoindigos make them desired candidates for understanding their mechanism of action. We have recently synthesized a novel group of pyridone-annelated isoindigos and identified the derivative 5'-Cl that is cytotoxic to various cancer cell lines. In the present study, we analyzed the effect of this compound on cell cycle of the promyelocytic leukemia cell line HL-60.

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