Open AccessTraditional Chinese Medicine Baicalin Suppresses mESCs Proliferation through Inhibition of miR-294 Expression
Author(s) -
Jian Wang,
Jacob Masika,
Jianxia Zhou,
Jun Wang,
Minyan Zhu,
Haitao Luo,
Xiancheng Zhang,
Zhang Liangpin,
Ming Tang,
Linlin Gao,
Juergen Hescheler,
Huamin Liang
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000373997
Subject(s) - baicalin , cell growth , propidium iodide , embryonic stem cell , cell cycle , chemistry , c jun , microbiology and biotechnology , cell , apoptosis , biology , biochemistry , transcription factor , gene , programmed cell death , high performance liquid chromatography , chromatography
Traditional Chinese herbal medicines (TCMs) have been widely used against a broad spectrum of biological activities, including influencing the cardiac differentiation from mouse embryonic stem cells (mESCs). However, their effects and mechanisms of action on ESCs proliferation remain to be determined. The present study aimed to determine the effect of three TCMs, baicalin, ginsenoside Rg1, and puerarin, on mESCs proliferation and to elucidate the possible mechanism of their action.