Genistein Stimulates Jejunum Chloride Secretion via an Akt-Mediated Pathway in Intact Female Mice | Zendy

Lana Leung | Zendy; Ashesh Bhakta | Zendy; Katherine Cotangco | Zendy; Layla AlNakkash | Zendy

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Genistein Stimulates Jejunum Chloride Secretion via an Akt-Mediated Pathway in Intact Female Mice

Author(s) -

Lana Leung,

Ashesh Bhakta,

Katherine Cotangco,

Layla AlNakkash

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373953

Subject(s) - endocrinology , medicine , basal (medicine) , ovariectomized rat , estrogen , protein kinase b , biology , chemistry , signal transduction , biochemistry , insulin

We have previously shown that daily subcutaneous injections with the naturally occurring phytoestrogen genistein (600 mg genistein/kg body weight/day, 600G) results in a significantly increased basal intestinal chloride, Cl(-), secretion (Isc, a measure of transepithelial secretion) in intact C57BL/6J female mice after 1-week of treatment, compared to controls (DMSO vehicle injected). Removal of endogenous estrogen via ovariectomy (OVX) had no effect on the 600G-mediated increase in basal Isc.

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