Open AccessImpact of Autophagy Inhibition at Different Stages on Cytotoxic Effect of Autophagy Inducer in Glioblastoma Cells
Author(s) -
Chenguang Li,
Yaohua Liu,
Huailei Liu,
Weiguang Zhang,
Chen Shen,
KenKa Cho,
Xin Chen,
Fei Peng,
Yunke Bi,
Xu Hou,
Yang Zhong,
Zhixing Zheng,
Kaikai Wang,
Xiaoxiong Wang,
Jiakang Zhang,
Zhong Chen,
Huichao Zou,
Xinjian Zhang,
Shen Zhao
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000373952
Subject(s) - autophagy , inducer , cytotoxic t cell , glioblastoma , cancer research , chemistry , cytotoxicity , microbiology and biotechnology , biology , apoptosis , in vitro , biochemistry , gene
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor with a poor prognosis. Combination treatment of autophagy inducer and autophagy inhibitor may be a feasible solution to improve the therapeutic effects. However, the correlation between them is unclear. The purpose of this study was to investigate the effect of autophagy inhibition at different stages on cytotoxicity of autophagy inducers in glioblastoma cells.