Open AccessMicroglia are Involved in Pruritus Induced by DNFB via the CX3CR1/p38 MAPK Pathway
Author(s) -
Ying Zhang,
Yan Jia,
Rong Hu,
Yu Sun,
Yu Ma,
Zhifeng Chen,
Hong Jiang
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000373929
Subject(s) - microglia , mapk/erk pathway , p38 mitogen activated protein kinases , cx3cr1 , microbiology and biotechnology , chemistry , cancer research , signal transduction , inflammation , medicine , pharmacology , chemokine , biology , immunology , chemokine receptor
Pruritus, also known as itch, is a common, unpleasant sensation that can be difficult to treat. Frequently, chronic itch is associated with the development of neuropathic pain resulting from nerve injury or insult. Previous studies have shown the involvement of spinal microglia in the development of neuropathic pain, but their role in chronic pruritus is unclear.