Open AccessAngiotensin II-Induced Egr-1 Expression is Suppressed by Peroxisome Proliferator- Activated Receptor-γ Ligand 15d-PGJ2 in Macrophages
Author(s) -
Yan Meng,
Chen Chen,
Changlin Tian,
Jie Du,
Huihua Li
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000369729
Subject(s) - angiotensin ii , proinflammatory cytokine , mapk/erk pathway , peroxisome proliferator activated receptor , chemistry , receptor , inflammation , signal transduction , microbiology and biotechnology , pharmacology , endocrinology , medicine , biology , biochemistry
Angiotensin II (Ang II) plays a critical role in regulating vascular inflammatory diseases, such as atherosclerosis and hypertension. Early growth response-1 (Egr-1) is an immediate early gene that acts as a master switch for the inflammatory response. However, the role of Ang II in regulating Egr-1 expression in macrophages, and the effect of peroxisome proliferators-activated receptor-γ (PPAR-γ) ligand 15d-PGJ2 in this process remain to be investigated.