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Pulmonary arterial endothelial plexiform lesions are a basic pathological change associated with pulmonary vascular remodeling and are characterized by the formation of tumorlets as a result of over-growth of endothelial cells. Accumulating evidence suggests that platelet-derived growth factor (PDGF) participates in regulating the progression of pulmonary arterial hypertension. However, whether PDGF promotes the survival of pulmonary arterial endothelial cells (PAECs), as well as the specific molecular mechanisms that underlie its actions, remains unknown.

cellular physiology and biochemistry

Platelet-Derived Growth Factor-B (PDGF-B) Induced by Hypoxia Promotes the Survival of Pulmonary Arterial Endothelial Cells through the PI3K/Akt/Stat3 Pathway