Platelet-Derived Growth Factor-B (PDGF-B) Induced by Hypoxia Promotes the Survival of Pulmonary Arterial Endothelial Cells through the PI3K/Akt/Stat3 Pathway | Zendy

Limin Li | Zendy; Mengyuan Xu | Zendy; Xiaoxia Li | Zendy; Chengfang Lv | Zendy; Xiaoqian Zhang | Zendy; Hongjuan Yu | Zendy; Mingwen Zhang | Zendy; Yueyue Fu | Zendy; Hongbin Meng | Zendy; Jin Zhou | Zendy

Open Access

Platelet-Derived Growth Factor-B (PDGF-B) Induced by Hypoxia Promotes the Survival of Pulmonary Arterial Endothelial Cells through the PI3K/Akt/Stat3 Pathway

Author(s) -

Limin Li,

Mengyuan Xu,

Xiaoxia Li,

Chengfang Lv,

Xiaoqian Zhang,

Hongjuan Yu,

Mingwen Zhang,

Yueyue Fu,

Hongbin Meng,

Jin Zhou

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369709

Subject(s) - protein kinase b , platelet derived growth factor receptor , pi3k/akt/mtor pathway , hypoxia (environmental) , biology , platelet derived growth factor , cancer research , stat3 , apoptosis , growth factor , microbiology and biotechnology , signal transduction , chemistry , biochemistry , receptor , organic chemistry , oxygen

Pulmonary arterial endothelial plexiform lesions are a basic pathological change associated with pulmonary vascular remodeling and are characterized by the formation of tumorlets as a result of over-growth of endothelial cells. Accumulating evidence suggests that platelet-derived growth factor (PDGF) participates in regulating the progression of pulmonary arterial hypertension. However, whether PDGF promotes the survival of pulmonary arterial endothelial cells (PAECs), as well as the specific molecular mechanisms that underlie its actions, remains unknown.

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