Open AccessAmbient Fine Particulate Matter Induces Apoptosis of Endothelial Progenitor Cells Through Reactive Oxygen Species Formation
Author(s) -
Yuqi Cui,
Xiaoyun Xie,
Fei Jia,
Jianfeng He,
Zhihong Li,
Mao Fu,
Hong Hao,
Ying Li,
Jason Z. Liu,
Peter J. Cowan,
Hua Zhu,
Qinghua Sun,
Zhenguo Liu
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000369701
Subject(s) - reactive oxygen species , superoxide dismutase , progenitor cell , apoptosis , population , glutathione peroxidase , chemistry , oxidative stress , immunology , microbiology and biotechnology , andrology , biology , stem cell , medicine , biochemistry , environmental health
Bone marrow (BM)-derived endothelial progenitor cells (EPCs) play a critical role in angiogenesis and vascular repair. Some environmental insults, like fine particulate matter (PM) exposure, significantly impair cardiovascular functions. However, the mechanisms for PM-induced adverse effects on cardiovascular system remain largely unknown. The present research was to study the detrimental effects of PM on EPCs and explore the potential mechanisms.