Modulation of FoxO1 Expression by miR-21 to Promote Growth of Pancreatic Ductal Adenocarcinoma | Zendy

Weifeng Song | Zendy; Qi Li | Zendy; Lei Wang | Zendy; Liwei Wang | Zendy

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Modulation of FoxO1 Expression by miR-21 to Promote Growth of Pancreatic Ductal Adenocarcinoma

Author(s) -

Weifeng Song,

Qi Li,

Lei Wang,

Liwei Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369686

Subject(s) - foxo1 , pancreatic ductal adenocarcinoma , cancer research , microrna , carcinogenesis , in vivo , biology , medicine , endocrinology , pancreatic cancer , signal transduction , cancer , gene , microbiology and biotechnology , biochemistry , protein kinase b

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal primary tumors in humans, with undetermined tumorigenesis. Although previous work by us, and by others, has clearly demonstrated an involvement of miR-21 in the growth of PDAC, the underlying mechanism has not been clarified.

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