Open AccessDistinct DNA Methylomes of Human Placentas Between Pre-Eclampsia and Gestational Diabetes Mellitus
Author(s) -
Lan Liu,
Xiang Zhang,
Can Rong,
Rui Cheng,
Hui Ji,
Yujia Qian,
Ruizhe Jia,
Lichao Sun
Publication year - 2014
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000366386
Subject(s) - dna methylation , epigenetics , gestational diabetes , placenta , biology , pregnancy , methylation , fetus , diabetes mellitus , microarray , endocrinology , medicine , bioinformatics , gene , andrology , gestation , genetics , gene expression
The placenta acts not only as a conduit of nutrient and waste exchange between mother and developing fetus but also functions as a regulator of the intrauterine environment. Pre-eclampsia (PE) and gestational diabetes mellitus (GDM) are leading causes of complications during pregnancy. Pathophysiologies show that they are associated with one another. Epigenetics provides a link between environmental factors that have previously been linked to poor pregnancy outcomes and fetal programming.